Rachele Allena

Contact

CV

Duties

• Editorial Board Member Scientific Reports
• Section Editor Mathematics in Medical and Life Sciences
• Chair of MECABIONIC at Université Côte d'Azur
• Member of the Scientific Council of the LJAD
• Chair of the Commission de la formation par la recherche of the LJAD

Research topics

• Computational biomechanics
• Mechanobiology
• Cell mechanics
• Bone mechanics

Teaching

• Undergraduate: Algebra, Analysis, Mathematics: continuous approaches, analysis and modelling, Cell mechanics, Differential equations, Statistics, Biomaterials behavior, Continuum mechanics, Cell and tissue engineering, Bioinstrumentation, MEMS, Composite structures behavior
• Graduate: Solid mechanics, Mathematical modelling for cell mechanics, Cell adhesion/motility, Cell biomechanics, Mechanics of biological tissues

Scientific supervision

• Minku Arora (2025-2026) - Numerical modelling of bone remodelling based on anisotropic damage
• Francesca Ballatore (2025-2026) - Multiphysics model of confined cell migration (ANR-24-CE45-0690)
• David Hernandez-Aristizabal (2024-2026) - In silico modelling of the mechanical interaction between the cell and the basal lamina during cancer invasion (INSERM LSP 296457)
• Marie Bernabeu (2024-...) - Mouvements cuspidiens sous contrainte occlusale: répercussions mécaniques sur les restaurations adhésives
• Nicolas Ruyssen (2019-2022) - Modèles numériques pour l’étude in vitro de la synapse immunologique B : de l’optimisation d’un système de capture microfluidique à l’estimation des forces de contact
• Jamie Frame (2016-2017) - Computational modelling of osseointegration of hydrogel implants
• Thomas Thenard (2017-2021) - Influence de la rugosité de surfaces Ti-6Al-4V obtenues par fabrication additive SLM sur l'ostéointégration : Évaluation in vitro et in silico
• Solenne Deveraux (2015-2018) - Modélisation de la mécanique de la cellule et son noyau dans le cadre de la migration confinée
• Mary Schmitt (2012-2015) - Analyses expérimentales et modélisation numérique de l’ostéogenèse au sein d’un implant poreux en titane.
• Samy Bendaya (2011-2014) - Etude comparative des paramètres pelviens, acétabulaires et fémoraux proximaux des hanches natives asymptomatiques, chez les coxarthroses et après PTH. Analyse par système EOS

Publications

1. R. Allena Computational analysis of region-specific bone remodeling in the human femur via strain energy decomposition., (2025)
2. R. Allena D. Scerrato, A. M. Bersani, I. Giorgio A bi-dimensional model bridging microdamage evolution and bone remodeling: A computational study on a human femur., (2025)
3. N. Ruyssen, G. Fina, R. Allena M.-C. Jullien, J. Fattaccioli Using lateral dispersion to optimise microfluidic trap array efficiency., (2025)
4. R. Allena, D. Scerrato, A. Bersani, I. Giorgio Simulating Bone Healing with Bio-Resorbable Scaffolds in a Three-Dimensional System: Insights into Graft Resorption and Integration., (2025)
5. R. Allena, Y. Rémond How can theramechanics drive bone remodeling?., (2025)
6. R. Allena Potential theramechanics for cancer invasion: an in silico study., (2024)
7. R. Allena A numerical study to discriminate between the hydrostatic and deviatoric strain energies impact on cells activity during bone remodelling., (2024)
8. R. Allena, D. Scerrato, A. Bersani, I. Giorgio Functional adaptation of bone mechanical properties using a diffusive stimulus originated by dynamic loads in bone remodelling., (2024)
9. R. Allena, Y. Rémond Theramechanics: how acting on mechanics will help conceiving new medical treatments., (2023)
10. R. Allena, D. Aubry Implicit implementation of the cell-micropillars interaction during cell drop under gravity., (2023)
11. R. Allena, D. Scerrato, A. M. Bersani, I. Giorgio A model for the bio-mechanical stimulus in bone remodelling as a diffusive signalling agent for bones reconstructed with bio-resorbable grafts., (2023)
12. L. Pinon, N. Ruyssen, J. Pineau, O. Mesdjian, D. Cuvelier, A. Chipont, R. Allena, C. L. Guerin, S. Asnacios, A. Asnascios, P. Pierobon, J. Fattaccioli Phenotyping Polarization Dynamics Of Immune Cells Using A Lipid Droplet - Cell Pairing Microfluidic Platform., (2022)
13. L. Pinon, N. Ruyssen, J. Pineau, O. Mesdjian, D. Cuvelier, R. Allena, S. Asnacios, A. Asnascios, P. Pierobon, J. Fattaccioli Onset and kinetics of B cell polarization depend on substrate mechanics and antigen concentration., (2022)
14. C. Perier-Metz, L. Corté, R. Allena, S. Checa A 3D in silico multi-tissue evolution model highlights the relevance of local strain accumulation in bone fracture remodeling., (2022)
15. D. George, S. Pallu, C. Bourzac, R. Wazzani, R. Allena, Y. Rémond, H. Portier Prediction of cortical bone thickness variations in the tibial diaphysis of running rats., (2022)
16. N. Ruyssen, G. Fina, R. Allena, M. C. Jullien, J. Fattaccioli Spanwise dispersion optimizes the efficiency of dense microfluidic trap arrays., (2021)
17. R. Allena, D. Aubry Nuclear Stress-strain State Over Micropillars: A Mechanical In Silico Study., (2021)
18. O. Mesdjian, N. Ruyssen, C. Jullien, R. Allena, J. Fattaccioli Enhancing the capture efficiency and homogeneity of single-layer flow-through trapping microfluidic devices using oblique hydrodynamic streams., (2021)
19. R. Allena, C. Cluzel Computational implementation of non-uniform orthotropic directions in the femoral diaphysis based on cortical bone microstructure to build a constitutive model., (2021)
20. T. Thenard, A. Catapano, R. Allena, M. El May, N. Saintier, M. Mesnard Topography and wettability characterization of surfaces manufacturedby SLM and treated by chemical etching, (2020)
21. T. Thenard, A. Catapano, M. Mesnard et R. Allena A Cellular Potts energy-based approach to analyse the influence of the surface topography on single cell motility, (2020)
22. D. George, R. Allena, C. Bourzac, S. Pallu, M. Bensidhoum, H. Portieret Y. Rémond How mechanobiological modelling of cellular activities can predict bone density evolution?, (2020)
23. D. George, R. Allena, C. Bourzac, S. Pallu, M. Bensidhoum, H. Portieret Y. Rémond A new comprehensive approach for bone remodeling under mediumand high mechanical load based on cellular activity, (2020)
24. S. Mondésert-Deveraux, D. Aubry, R. Allena In silico approach to quantify nucleus self-deformation on micropillared substrates, (2019)
25. D. George, R. Allena, Y. Rémond Integrating molecular and cellular kinetics into a coupled continuum mechanobiological stimulus for bone reconstruction, (2019)
26. J. Frame, P.-Y. Rohan, L. Corté, R. Allena A mechano-biological model of multi-tissue evolution in bone, (2019)
27. P. Davidson, G. Fedorchack, S. Mondésert-Deveraux, E. Bell, P. Isermann, D. Aubry, R. Allena, J. Lammerding High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cells, (2019)
28. R. Allena, C. Cluzel Heterogeneous directions of orthotropy in three-dimensional structures: finite element description based on diffusion equations, (2018)
29. D. George, R. Allena, Y. Rémond A multiphysics stimulus for continuum mechanics bone remodeling, (2018)
30. C. Cluzel, R. Allena A general method for the determination of the local orthotropic directions of heterogeneous materials: application to bone structures using μCT images, (2018)
31. R. Allena The discriminant role of mechanics during cell migration, (2018)
32. D. George, R. Allena, Y. Rémond Cell nutriments and motility for mechanobiological bone remodeling in the context of orthodontic periodontal ligament deformation, (2018)
33. J. Frame, P.-Y. Rohan, L. Corté, R. Allena Optimal bone structure is dependent on the interplay between mechanics and cellular activities, (2018)
34. S. Mondésert-Deveraux, R. Allena, D. Aubry A coupled friction-poroelasticity model of chimneying shows that confined cells can mechanically migrate without adhesions, (2018)
35. S. Mondésert-Deveraux, R. Allena, D. Aubry A numerical model suggests the interplay between nuclear plasticity and stiffness during a perfusion assay, (2017)
36. D. George, R. Allena, Y. Rémond Mechanobiological stimuli for bone remodeling: mechanical energy, cell nutriments and mobility, (2017)
37. S. Bendaya, C. Anglin, J.-Y. Lazennec, R. Allena, P. Thoumie, W. Skalli Good vs poor results after total hip arthroplasty: an analysis method using implant and anatomic parameters with the EOS imaging system, (2016)
38. R. Allena, M. Scianna, L. Preziosi A Cellular Potts Model of single cell migration in presence of durotaxis, (2016)
39. M. Schmitt, R. Allena, T. Schouman, S. Frasca, J.-M. Collombet, P. Rouch Diffusion model to describe osteogenesis within a porous titanium scaffold, (2016)
40. R. Allena, H. Thiam, M. Piel, D. Aubry A mechanical model to investigate the role of the nucleus during confined cell migration, (2015)
41. S. Mondésert-Deveraux, R. Allena, D. Aubry Viscoelastoplastic model of cell nucleus under compression, (2015)
42. R. Allena Computational modelling of cell mechanics: from osteogenesis down to collective and single cell migration, (2015)
43. D. Aubry, M. Gupta, B. Ladoux, R. Allena Mechanical link between durotaxis, cell polarity and anisotropy during cell migration, (2015)
44. S. Bendaya, J.-Y. Lazennec, C. Anglin, R. Allena, N. Sellam, P. Thoumie, W. Skalli Healthy vs. osteoarthritic hips: A comparison of hip, pelvis and femoral parameters and relationships using the EOS® system, (2015)
45. C. Cluzel, R. Allena Modelling of anisotropic cortical bone based on degradation mechanism, (2015)
46. D. Aubry, H. Thiam, M. Piel, R. Allena A computational mechanics approach to assess the link between cell morphology and forces during confined migration, (2015)
47. R. Allena, P. K. Maini Reaction–diffusion finite element model of lateral line primordium migration to explore cell leadership, (2014)
48. R. Allena, C. Cluzel Identification of anisotropic tensile strength of cortical bone using Brazilian test, (2014)
49. R. Allena Mechanical modelling of confined cell migration across constricted-curved micro-channels, (2014)
50. R. Allena, D. Aubry, J. Sharpe On the mechanical interplay between intra-and inter-synchronization during collective cell migration: a numerical investigation, (2013)
51. M. Schmitt, P. Rouch, Y. Tillier, T. Schouman, R. Allena Diffusion–reaction model to describe osteogenesis within a titanium scaffold, (2013)
52. R. Allena, J. Muñoz, D. Aubry Diffusion-reaction model for Drosophila embryo development, (2013)
53. R. Allena Cell migration with multiple pseudopodia: temporal and spatial sensing models, (2013)
54. R. Allena, D. Aubry A purely mechanical model to explore amoeboid cell migration, (2012)
55. R. Allena, D. Aubry ‘Run-and-tumble’or ‘look-and-run’? A mechanical model to explore the behavior of a migrating amoeboid cell, (2012)
56. R. Allena, D. Aubry An extensive numerical simulation of the cephalic furrow formation in Drosophila embryo, (2012)
57. R. Allena, D. Aubry Coupling ALE Technique and Harmonic Parametrization to Describe Concurrent and Successive Elementary Cell Deformations, (2011)
58. R. Allena, D. Aubry A novel technique to parametrize shell-like deformations inside biological membranes, (2011)
59. R. Allena, A.-S. Mouronval, D. Aubry Simulation of multiple morphogenetic movements in the Drosophila embryo by a single 3D finite element model, (2011)
60. R. Allena Numerical simulation of morphogenetic movements in Drosophila embryo, (2009)